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Updated: Sep 04, 2026

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USMLE exam is designed to assess a candidate's ability to apply their medical knowledge and skills to real-life medical scenarios. USMLE exam is divided into three steps, with each step building on the previous one. Step 1 evaluates the candidate's basic medical knowledge and understanding of concepts, while Step 2 assesses their ability to apply that knowledge to clinical scenarios. Step 3 is a two-day exam that tests the candidate's ability to make clinical judgments and decisions.

The United States Medical Licensing Examination (USMLE) is a three-step exam that is necessary for medical licensure in the United States. The USMLE is designed to assess a physician's ability to apply knowledge, concepts, and principles, and to determine if they are ready to provide safe and effective patient care. USMLE exam is taken by graduates of medical schools in the US and Canada, as well as international medical graduates who wish to practice medicine in the US.

Reference: http://www.usmle.org/step-1/#question-formats

USMLE USMLE Exam Overview:

Certification Vendor:USMLE
Exam Name:United States Medical Licensing Examination
Exam Number:USMLE
Exam Price:USD 680
Passing Score:Pass/Fail (Step 1)
Real Exam Qty:Up to 280 (Step 1)
Certificate Validity Period:No fixed expiration; subject to individual state medical licensure requirements
Exam Format:Single Best Answer Questions, Computer-based Examination, Multiple Choice Questions (MCQs)
Available Languages:English
Exam Duration:480 (Step 1)
Related Certifications:USMLE Step 3
USMLE Step 1
USMLE Step 2 Clinical Knowledge (CK)
Sample Questions:USMLE USMLE Sample Questions
Exam Way:Computer-based examination administered at Prometric test centers worldwide.
Pre Condition:Applicants must meet eligibility requirements established by USMLE, including enrollment in or graduation from an accredited medical school recognized by the appropriate authorities.
Official Syllabus URL:https://www.usmle.org/

USMLE USMLE Exam Syllabus Topics:

SectionObjectives
Central and Peripheral Nervous Systems- Neurologic Disorders
  • 1. Neuropathology
  • 2. Neuroanatomy
  • 3. Neurologic Diseases
Human Development- Growth and Development
  • 1. Developmental Abnormalities
  • 2. Embryology
Multisystem Processes and Disorders- Systemic Conditions
  • 1. Nutrition
  • 2. Neoplasia
  • 3. Infectious Diseases
General Principles- Foundational Medical Sciences
  • 1. Genetics
  • 2. Immunology
  • 3. Biochemistry
  • 4. Microbiology
  • 5. Physiology
  • 6. Behavioral Sciences
  • 7. Pathology
  • 8. Pharmacology
Endocrine System- Hormonal Regulation and Disease
  • 1. Adrenal Disorders
  • 2. Pituitary Disorders
  • 3. Thyroid Disorders
Cardiovascular System- Cardiac and Vascular Disorders
  • 1. Vascular Pathology
  • 2. Heart Disease
Skin and Related Connective Tissue- Dermatologic Conditions
  • 1. Skin Neoplasms
  • 2. Inflammatory Skin Disorders
Respiratory System- Pulmonary Medicine
  • 1. Airway Disorders
  • 2. Lung Diseases
Hematopoietic and Lymphoreticular Systems- Blood and Immune Disorders
  • 1. Leukemias and Lymphomas
  • 2. Anemias
  • 3. Coagulation Disorders
Gastrointestinal System- Digestive System Disorders
  • 1. Liver Disease
  • 2. Gastrointestinal Pathology
Renal and Urinary System- Kidney and Urinary Disorders
  • 1. Renal Physiology
  • 2. Renal Pathology
Musculoskeletal System- Bones, Joints, and Muscles
  • 1. Orthopedic Disorders
  • 2. Rheumatologic Diseases
Reproductive System- Male and Female Reproductive Health
  • 1. Reproductive Physiology
  • 2. Reproductive Disorders

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Online Test Engine can supports Windows / Mac / Android / iOS, etc., because it is the software based on WEB browser. You can use it on any electronic device and practice with self-paced.
Online Test Engine supports offline practice, while the precondition is that you should run it with the internet at the first time.
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PDF Version: can be read under the Adobe reader, or many other free readers, including OpenOffice, Foxit Reader and Google Docs.

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